BDBM50542209 CHEMBL4640401

SMILES Cc1ccc(cc1C#Cc1cnc2cccnn12)C(=O)Nc1ccc(CN2CCN(CC2)C(=O)CCCc2cn(CCOCCOCCOCCNc3cccc4C(=O)N(C5CCC(=O)NC5=O)C(=O)c34)nn2)c(c1)C(F)(F)F

InChI Key InChIKey=SVYYVGZMWJYFIE-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50542209   

TargetTyrosine-protein kinase ABL1(Human)
Tsinghua University

Curated by ChEMBL
LigandPNGBDBM50542209(CHEMBL4640401)
Affinity DataIC50: 13nMAssay Description:Inhibition of human ABL T315I mutant using EAIYAAPFAKKK substrate and [gamma-33P]-ATP incubated for 40 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lyn(Human)
Tsinghua University

Curated by ChEMBL
LigandPNGBDBM50542209(CHEMBL4640401)
Affinity DataIC50: 44nMAssay Description:Inhibition of human LYN using poly(Glu,Tyr)4:1 substrate and [gamma-33P]-ATP incubated for 40 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Tsinghua University

Curated by ChEMBL
LigandPNGBDBM50542209(CHEMBL4640401)
Affinity DataIC50: 2.58E+3nMAssay Description:Inhibition of human c-SRC using poly(Glu,Tyr)4:1 substrate and [gamma-33P]-ATP incubated for 40 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Tsinghua University

Curated by ChEMBL
LigandPNGBDBM50542209(CHEMBL4640401)
Affinity DataIC50: 441nMAssay Description:Inhibition of human VEGFR2 using MBP substrate and [gamma-33P]-ATP incubated for 40 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed