BDBM50542111 CHEMBL4644763

SMILES C1C[C@@H](CN1)Oc1ccc2cncc(-c3cnc4[nH]ccc4c3)c2c1

InChI Key InChIKey=QAVZVAORORKNHF-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50542111   

TargetProtein kinase C zeta type(Human)
Asahi Kasei Pharma

Curated by ChEMBL
LigandPNGBDBM50542111(CHEMBL4644763)
Affinity DataIC50: 13nMAssay Description:Inhibition of recombinant human PKCzeta using biotin-KKKKRFSFKKSFK substrate and ATP incubated for 30 mins by TR-FRET methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetProtein kinase C zeta type(Human)
Asahi Kasei Pharma

Curated by ChEMBL
LigandPNGBDBM50542111(CHEMBL4644763)
Affinity DataIC50: 8.00E+3nMAssay Description:Inhibition of PKCzeta in human THP1 cells assessed as reduction in LPS-induced TNFalpha production pre-incubated for 60 mins before LPS simulations f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetProtein kinase C zeta type(Human)
Asahi Kasei Pharma

Curated by ChEMBL
LigandPNGBDBM50542111(CHEMBL4644763)
Affinity DataIC50: 13nMAssay Description:Inhibition of recombinant human PKCzeta using biotin-KKKKRFSFKKSFKC as substrate measured by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed