BDBM50542089 CHEMBL4646522::US20250114338, Example 167

SMILES C[C@@H]1Cc2c([nH]c3ccccc23)[C@H](N1CC(C)(C)F)c1c(F)cc(OC2CN(CC#C)C2)cc1F

InChI Key InChIKey=YJGQQJPEEYBAQU-UHFFFAOYSA-N

Data  1 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50542089   

TargetEstrogen receptor(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50542089(CHEMBL4646522 | US20250114338, Example 167)
Affinity DataIC50: 0.0830nMAssay Description:Induction of ERalpha degradation in human MCF7 cells after 4 hrs by FITC/Hoechst staining based immunofluorescence imaging analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetEstrogen receptor(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50542089(CHEMBL4646522 | US20250114338, Example 167)
Affinity DataEC50:  0.0830nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2025
Entry Details
Go to US Patent