BDBM50542087 CHEMBL4635493::US11672785, Goodacre Compound 107::US20240131013, Goodacre Compound 107

SMILES CCCN1CC(C1)Oc1cc(F)c([C@H]2N(CC(C)(C)F)[C@H](C)Cc3c2[nH]c2ccccc32)c(F)c1

InChI Key InChIKey=VJYIQQTZNGFHGR-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50542087   

TargetEstrogen receptor(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50542087(CHEMBL4635493 | US11672785, Goodacre Compound 107 ...)
Affinity DataIC50: 0.0650nMAssay Description:Induction of ERalpha degradation in human MCF7 cells after 4 hrs by FITC/Hoechst staining based immunofluorescence imaging analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetEstrogen receptor(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50542087(CHEMBL4635493 | US11672785, Goodacre Compound 107 ...)
Affinity DataIC50: 2.82nMAssay Description:Compounds were screened for their ability to displace a fluorescent labelled tracer ERβ ligand via time resolved fluorescent energy transfer usi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2023
Entry Details
Go to US Patent

TargetSteroid hormone receptor ERR1(Human)
Olema Pharmaceuticals

US Patent
LigandPNGBDBM50542087(CHEMBL4635493 | US11672785, Goodacre Compound 107 ...)
Affinity DataIC50: 2.82nMAssay Description:Compounds were screened for their ability to displace a fluorescent labelled tracer ERα ligand via time resolved fluorescent energy transfer usi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2024
Entry Details
Go to US Patent