BDBM50542084 CHEMBL4648503::US20250114338, Example 128

SMILES C[C@@H]1Cc2c([nH]c3ccccc23)[C@H](N1CC(C)(C)F)c1c(F)cc(OCCN2CC(C2)C(F)F)cc1F

InChI Key InChIKey=LCQOUZXBODLZRK-UHFFFAOYSA-N

Data  1 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50542084   

TargetEstrogen receptor(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50542084(CHEMBL4648503 | US20250114338, Example 128)
Affinity DataIC50: 0.0900nMAssay Description:Induction of ERalpha degradation in human MCF7 cells after 4 hrs by FITC/Hoechst staining based immunofluorescence imaging analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetEstrogen receptor(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50542084(CHEMBL4648503 | US20250114338, Example 128)
Affinity DataEC50:  0.0270nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2025
Entry Details
Go to US Patent

TargetEstrogen receptor(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50542084(CHEMBL4648503 | US20250114338, Example 128)
Affinity DataEC50:  0.0640nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2025
Entry Details
Go to US Patent