BDBM50542057 CHEMBL4639561::US11274090, Example 56 Isomer 2

SMILES Cn1cc(cn1)-c1cnc(NC(=O)[C@H](NCCc2ccc(cc2)C#N)c2ccccc2)cn1

InChI Key InChIKey=BNJIGTSAPAJMFC-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50542057   

TargetHistone acetyltransferase p300(Human)
Constellation Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50542057(CHEMBL4639561 | US11274090, Example 56 Isomer 2)
Affinity DataIC50: 460nMAssay Description:Binding affinity to recombinant N-terminal His-tagged EP300 HAT domain (unknown origin) (1287 to 1666 residues) expressed in Escherichia coli incubat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetHistone acetyltransferase p300(Human)
Constellation Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50542057(CHEMBL4639561 | US11274090, Example 56 Isomer 2)
Affinity DataIC50: 5.00E+3nMAssay Description:The full length p300 SPA assay was run following the same protocol as p300 HAT SPA assay, but used 6 nM purified full length p300 (purchased from Act...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/4/2022
Entry Details
Go to US Patent