BDBM50542023 CHEMBL4649653

SMILES COc1ccc(C(=O)N2[C@H](C)CN(C[C@H]2C)C(=O)c2ccc3cc[nH]c3c2)c(F)c1

InChI Key InChIKey=WTXZRSDVMFYIFC-UHFFFAOYSA-N

Data  2 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50542023   

TargetCarbamoyl-phosphate synthase [ammonia], mitochondrial(Human)
H3 Biomedicine

Curated by ChEMBL

LigandBDBM50542023(CHEMBL4649653)Copy SMILESCopy InChI

Affinity DataIC50: 66nMAssay Description:Allosteric inhibition of His-tagged CPS1 (unknown origin) expressed in baculovirus infected Sf21 insect cells assessed as reduction in ADP level prei...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
8/13/2021
Entry Details Article
Copy Entry DOIPubMed
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TargetCarbamoyl-phosphate synthase [ammonia], mitochondrial(Human)
H3 Biomedicine

Curated by ChEMBL

LigandBDBM50542023(CHEMBL4649653)Copy SMILESCopy InChI

Affinity DataIC50: 240nMAssay Description:Inhibition of CPS1 in human pooled hepatocytes assessed as reduction in urea production measured after 16 hrs in presence of NH4Cl by tecan-plate rea...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
8/13/2021
Entry Details Article
Copy Entry DOIPubMed
Copy Rxn URL