BDBM50541819 CHEMBL4645406::US11530219, Compound 17

SMILES CN(c1ccccc1)c1nccc(NCC(=O)Nc2cccc3C(=O)N(Cc23)C2CCC(=O)NC2=O)n1

InChI Key InChIKey=BBLBXFIBZWEJOP-UHFFFAOYSA-N

Data  2 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50541819   

TargetBromodomain-containing protein 4(Human)
Usona Institute

Curated by ChEMBL
LigandPNGBDBM50541819(CHEMBL4645406 | US11530219, Compound 17)
Affinity DataIC50: 3.44E+3nMAssay Description:Inhibition of BRD4 bromodomain 2 (unknown origin) in HEK293 cells cotransfected with eGFP by flow cytometry based mCherry reporter gene analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetProtein cereblon(Human)
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM50541819(CHEMBL4645406 | US11530219, Compound 17)
Affinity DataIC50: 3.44E+3nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2023
Entry Details
Go to US Patent

TargetProtein cereblon(Human)
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM50541819(CHEMBL4645406 | US11530219, Compound 17)
Affinity DataKi:  970nMAssay Description:Binding affinity to CBRN (unknown origin) incubated for 60 mins by lenalidomide displacement assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetProtein cereblon(Human)
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM50541819(CHEMBL4645406 | US11530219, Compound 17)
Affinity DataKi:  970nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2023
Entry Details
Go to US Patent