BDBM50541702 CHEMBL4646010::US11926614, Example 189

SMILES Fc1ccc(nc1)C(=O)N[C@H]1C[C@@H](C1)c1nnc(-c2ccccn2)n1-c1ccccc1F

InChI Key InChIKey=SVDUOSYBBYZAAB-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50541702   

TargetPoly [ADP-ribose] polymerase tankyrase-2(Human)
University of Oslo

Curated by ChEMBL
LigandPNGBDBM50541702(CHEMBL4646010 | US11926614, Example 189)
Affinity DataIC50: 14nMAssay Description:Inhibition of human TNKS2 (873 to 1162 residues) measured after 20 hrs in presence of NAD+ by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase tankyrase-1/tankyrase-2(Human)
University of Oslo

Curated by ChEMBL
LigandPNGBDBM50541702(CHEMBL4646010 | US11926614, Example 189)
Affinity DataIC50: 17nMAssay Description:Inhibition of TNKS1/TNKS2 (unknown origin) expressed in HEK293 cells assessed as reduction in Wnt-signaling measured after 24 hrs by dual-glo lucifer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase tankyrase-2(Human)
University of Oslo

Curated by ChEMBL
LigandPNGBDBM50541702(CHEMBL4646010 | US11926614, Example 189)
Affinity DataIC50: 14nMAssay Description:Biochemical IC50 values for the following compounds were determined in accordance with the following protocol (see also Anumala et al., Discovery of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/23/2024
Entry Details
Go to US Patent