BDBM50541272 CHEMBL4643620

SMILES COc1cccc(CN2CCc3cc(ccc3C2=O)-c2ccc3[nH]ncc3c2)c1

InChI Key InChIKey=XTPHWCDWCWGAAN-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50541272   

TargetRho-associated protein kinase 1(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50541272(CHEMBL4643620)
Affinity DataIC50: 2.06E+3nMAssay Description:Inhibition of recombinant human ROCK1 (17 to 535 residues) using KEAKEKRQEQIAKRRRLSSLRASTSKSGGSQK as substrate incubated for 40 mins in presence of [...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetRho-associated protein kinase 2(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50541272(CHEMBL4643620)
Affinity DataIC50: 632nMAssay Description:Inhibition of recombinant human ROCK2 (11 to 552 residues) using KEAKEKRQEQIAKRRRLSSLRASTSKSGGSQK as substrate incubated for 40 mins in presence of [...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetRho-associated protein kinase 2(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50541272(CHEMBL4643620)
Affinity DataIC50: 632nMAssay Description:Inhibition of wild type partial length human ROCK1 (M1 to T431 residues) expressed in Mammalian expression system by Euro-fins kinase profiler assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetRho-associated protein kinase 1(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50541272(CHEMBL4643620)
Affinity DataIC50: 2.06E+3nMAssay Description:Inhibition of wild type partial length human ROCK1 (M1 to R415 residues) expressed in mammalian expression system by Euro-fins kinase profiler assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed