BDBM50541112 CHEMBL4641864

SMILES [O-][N+](=O)c1ccc(cc1)C(=O)Nc1nc2ccccc2s1

InChI Key InChIKey=GOKOILBJPWVKQU-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50541112   

Target72 kDa type IV collagenase(Human)
"A. Moro" University of Bari

Curated by ChEMBL
LigandPNGBDBM50541112(CHEMBL4641864)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of recombinant human MMP2 catalytic domain (Tyr110 to Asp452 residues) expressed in yeast cells using Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2/...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetNeutrophil collagenase(Human)
"A. Moro" University of Bari

Curated by ChEMBL
LigandPNGBDBM50541112(CHEMBL4641864)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of recombinant human MMP8 catalytic domain (Phe99 to Gln269 residues) expressed in Escherichia coli cells using Mca-Pro-Leu-Gly-Leu-Dpa-Al...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetMatrix metalloproteinase-9(Human)
"A. Moro" University of Bari

Curated by ChEMBL
LigandPNGBDBM50541112(CHEMBL4641864)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of recombinant human MMP9 catalytic domain (Phe107 to Pro449 residues) expressed in Escherichia coli cells using Mca-Pro-Leu-Gly-Leu-Dpa-A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetCollagenase 3(Human)
"A. Moro" University of Bari

Curated by ChEMBL
LigandPNGBDBM50541112(CHEMBL4641864)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of recombinant human MMP13 catalytic domain (Tyr104 to Asn274 residues) expressed in Escherichia coli cells using Mca-Pro-Leu-Gly-Leu-Dpa-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetStearoyl-CoA desaturase(Human)
Ut Southwestern Medical Center

Curated by ChEMBL
LigandPNGBDBM50541112(CHEMBL4641864)
Affinity DataIC50: 140nMAssay Description:Inhibition of SCD in human NCI-H2122 cells expressing CYP4F11 assessed as reduction in cell viability incubated for 96 hrs by cell titer Glo reagent ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetStearoyl-CoA desaturase(Human)
Ut Southwestern Medical Center

Curated by ChEMBL
LigandPNGBDBM50541112(CHEMBL4641864)
Affinity DataIC50: 2.20E+4nMAssay Description:Inhibition of SCD in human H2009 cells non-expressing CYP4F11 assessed as reduction in cell viability incubated for 96 hrs by cell titer Glo reagent ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed