BDBM50540044 CHEMBL4644729
SMILES C[C@@H](Nc1nc2n(ncc2c(=O)n1Cc1ccc(F)cc1)C(C)(C)C)c1ccc(Cl)cc1
InChI Key InChIKey=BOOYHBPHFVNWNH-UHFFFAOYSA-N
Data 18 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 18 hits for monomerid = 50540044
TargetHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Human)
Sun Yat-Sen University
Curated by ChEMBL
Sun Yat-Sen University
Curated by ChEMBL
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PDE9A2 (181 to 506 residues) (unknown origin) using [3H]-cGMP substrate incubated for 15 mins by liquid scintillation counting method r...More data for this Ligand-Target Pair
TargetDual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C(Human)
Rural Federal University of Rio De Janeiro
Curated by ChEMBL
Rural Federal University of Rio De Janeiro
Curated by ChEMBL
Affinity DataIC50: 2.90nMAssay Description:Inhibition of PDE1C (unknown origin)More data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Sun Yat-Sen University
Curated by ChEMBL
Sun Yat-Sen University
Curated by ChEMBL
Affinity DataIC50: 1.10E+4nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
Affinity DataIC50: 6.60E+3nMAssay Description:Inhibition of human CYP2C9More data for this Ligand-Target Pair
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of human CYP3A4 using midazolam as substrateMore data for this Ligand-Target Pair
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of human CYP3A4 using testosterone as substrateMore data for this Ligand-Target Pair
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of human CYP2D6More data for this Ligand-Target Pair
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of human CYP1A2More data for this Ligand-Target Pair
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Human)
Sun Yat-Sen University
Curated by ChEMBL
Sun Yat-Sen University
Curated by ChEMBL
Affinity DataIC50: 1.77E+3nMAssay Description:Inhibition of PDE10A (449 to 770 residues) (unknown origin) using [3H]-cAMP substrate incubated for 15 mins by liquid scintillation counting method r...More data for this Ligand-Target Pair
TargetDual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C(Human)
Rural Federal University of Rio De Janeiro
Curated by ChEMBL
Rural Federal University of Rio De Janeiro
Curated by ChEMBL
Affinity DataIC50: 2.90nMAssay Description:Inhibition of PDE1C2 (147 to 531 residues) (unknown origin) using [3H]-cGMP substrate incubated for 15 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
TargetHigh affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A(Human)
Sun Yat-Sen University
Curated by ChEMBL
Sun Yat-Sen University
Curated by ChEMBL
Affinity DataIC50: 2.02E+3nMAssay Description:Inhibition of PDE8A1 (480 to 820 residues) (unknown origin) using [3H]-cAMP substrate incubated for 15 mins by liquid scintillation counting method r...More data for this Ligand-Target Pair
TargetHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A(Human)
Sun Yat-Sen University
Curated by ChEMBL
Sun Yat-Sen University
Curated by ChEMBL
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PDE7A1 (130 to 482 residues) (unknown origin) using [3H]-cAMP substrate incubated for 15 mins by liquid scintillation counting method r...More data for this Ligand-Target Pair
TargetCone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'(Human)
Sun Yat-Sen University
Curated by ChEMBL
Sun Yat-Sen University
Curated by ChEMBL
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PDE6C (1 to 858 residues) (unknown origin) using [3H]-cGMP substrate incubated for 15 mins by liquid scintillation counting method rela...More data for this Ligand-Target Pair
Affinity DataIC50: 370nMAssay Description:Inhibition of PDE5A1 (535 to 860 residues) (unknown origin) using [3H]-cGMP substrate incubated for 15 mins by liquid scintillation counting method r...More data for this Ligand-Target Pair
Affinity DataIC50: 699nMAssay Description:Inhibition of PDE4D2 (86 to 413 residues) (unknown origin) using [3H]-cAMP substrate incubated for 15 mins by liquid scintillation counting method re...More data for this Ligand-Target Pair
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A(Human)
Sun Yat-Sen University
Curated by ChEMBL
Sun Yat-Sen University
Curated by ChEMBL
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PDE3A (679 to 1087 residues) (unknown origin) using [3H]-cAMP substrate incubated for 15 mins by liquid scintillation counting method r...More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PDE2A (580 to 919 residues) (unknown origin) using [3H]-cGMP substrate incubated for 15 mins by liquid scintillation counting method re...More data for this Ligand-Target Pair
TargetDual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B(Human)
Sun Yat-Sen University
Curated by ChEMBL
Sun Yat-Sen University
Curated by ChEMBL
Affinity DataIC50: 2.90nMAssay Description:Inhibition of PDE1B (146 to 506 residues) (unknown origin) using [3H]-cGMP substrate incubated for 15 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair