BDBM50539846 CHEMBL4648820

SMILES [H][C@@]12C[C@H](c3cc(=O)[nH]c4n[nH]c(C)c34)[C@@]([H])(C[C@H]1CC#N)C2

InChI Key InChIKey=KGKZRAAHCZTDQA-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50539846   

TargetTyrosine-protein kinase JAK1(Human)
Gvk Biosciences

Curated by ChEMBL
LigandPNGBDBM50539846(CHEMBL4648820)
Affinity DataIC50: 47nMAssay Description:Inhibition of N-terminal GST-tagged human JAK1 catalytic domain (850 to 1154 residues) incubated for 40 mins in presence of TK substrate-biotin by TR...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Gvk Biosciences

Curated by ChEMBL
LigandPNGBDBM50539846(CHEMBL4648820)
Affinity DataIC50: 360nMAssay Description:Inhibition of N-terminal His-tagged human JAK2 catalytic domain incubated for 20 mins in presence of TK substrate-biotin by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Gvk Biosciences

Curated by ChEMBL
LigandPNGBDBM50539846(CHEMBL4648820)
Affinity DataIC50: 970nMAssay Description:Inhibition of N-terminal His-tagged human JAK3 catalytic domain incubated for 20 mins in presence of TK substrate-biotin by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Gvk Biosciences

Curated by ChEMBL
LigandPNGBDBM50539846(CHEMBL4648820)
Affinity DataIC50: 330nMAssay Description:Inhibition of N-terminal GST-tagged human TYK2 catalytic domain (871 to 1187 residues) incubated for 40 mins in presence of TK substrate-biotin by TR...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Gvk Biosciences

Curated by ChEMBL
LigandPNGBDBM50539846(CHEMBL4648820)
Affinity DataIC50: 2.70E+3nMAssay Description:Inhibition of JAK1 in human STAT6-bla-RA1 cells assessed as reduction in IL4-induced STAT6-signalling pre-incubated for 1 hrs before human recombinan...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Gvk Biosciences

Curated by ChEMBL
LigandPNGBDBM50539846(CHEMBL4648820)
Affinity DataIC50: 4.30E+4nMAssay Description:Inhibition of JAK2 in human STAT5-irf1-bla TF1 cells assessed as reduction in EPO-induced STAT5-signalling pre-incubated for 1 hrs before EPO additio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed