BDBM50539830 CHEMBL4632897

SMILES Cc1[nH]nc2[nH]c(=O)cc([C@H]3CC[C@@H](CC3)NC(=O)C3CCCC3)c12

InChI Key InChIKey=NCLWUEGWKKBNEJ-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50539830   

TargetTyrosine-protein kinase JAK1(Human)
Gvk Biosciences

Curated by ChEMBL
LigandPNGBDBM50539830(CHEMBL4632897)
Affinity DataIC50: 110nMAssay Description:Inhibition of N-terminal GST-tagged human JAK1 catalytic domain (850 to 1154 residues) incubated for 40 mins in presence of TK substrate-biotin by TR...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Gvk Biosciences

Curated by ChEMBL
LigandPNGBDBM50539830(CHEMBL4632897)
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of N-terminal His-tagged human JAK2 catalytic domain incubated for 20 mins in presence of TK substrate-biotin by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Gvk Biosciences

Curated by ChEMBL
LigandPNGBDBM50539830(CHEMBL4632897)
Affinity DataIC50: 4.80E+3nMAssay Description:Inhibition of N-terminal His-tagged human JAK3 catalytic domain incubated for 20 mins in presence of TK substrate-biotin by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Gvk Biosciences

Curated by ChEMBL
LigandPNGBDBM50539830(CHEMBL4632897)
Affinity DataIC50: 6.80E+3nMAssay Description:Inhibition of N-terminal GST-tagged human TYK2 catalytic domain (871 to 1187 residues) incubated for 40 mins in presence of TK substrate-biotin by TR...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Gvk Biosciences

Curated by ChEMBL
LigandPNGBDBM50539830(CHEMBL4632897)
Affinity DataIC50: 9.10E+3nMAssay Description:Inhibition of JAK1 in human STAT6-bla-RA1 cells assessed as reduction in IL4-induced STAT6-signalling pre-incubated for 1 hrs before human recombinan...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Gvk Biosciences

Curated by ChEMBL
LigandPNGBDBM50539830(CHEMBL4632897)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of JAK2 in human STAT5-irf1-bla TF1 cells assessed as reduction in EPO-induced STAT5-signalling pre-incubated for 1 hrs before EPO additio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed