BDBM50539749 CHEMBL4643600

SMILES CN1CCC[C@H]1COc1nc2CN(CCc2c(n1)N1CCN(C(CO)C1)C(=O)C=C)c1cccc2ccccc12

InChI Key InChIKey=DOBSCEYVFQNYML-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50539749   

TargetGTPase KRas(Human)
Array Biopharma

Curated by ChEMBL
LigandPNGBDBM50539749(CHEMBL4643600)
Affinity DataIC50: 4.63E+3nMAssay Description:Inhibition of KRAS G12C mutant in human NCI-H358 cells assessed as reduction in ERK phosphorylation incubated for 3 hrs by in-cell western methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed