BDBM50538943 CHEMBL4640097

SMILES CCNC(=O)c1ccc(cn1)-c1c(C)nc2c(OCc3ccc(cc3)-c3ccccc3)cccn12

InChI Key InChIKey=VNNXRQLFCKSSMH-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50538943   

TargetPresenilin-1(Human)
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM50538943(CHEMBL4640097)
Affinity DataIC50: 91nMAssay Description:Modulatory activity of gamma secretase in human SKNBE2 cells assessed as decrease in Abeta42 levels incubated for 6 hrs by sandwich ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM50538943(CHEMBL4640097)
Affinity DataIC50: 91nMAssay Description:Inhibition of gamma-secretase in human SK-N-BE cells assessed as decrease in amyloid beta 42 production treated for 6 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed