BDBM50538678 CHEMBL4642520

SMILES CN(C)c1ccc(C=CC=Cc2cc(C)[n+](CCCCCc3c[nH]cn3)c(C)c2)cc1

InChI Key InChIKey=JECYYTFAWYJNHN-UHFFFAOYSA-N

Data  4 KI  6 Kd  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50538678   

TargetHistamine H4 receptor(Human)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50538678(CHEMBL4642520)
Affinity DataEC50:  72nMAssay Description:Agonist activity at human H4R expressed in HEK293-SF-hH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50538678(CHEMBL4642520)
Affinity DataEC50:  65nMAssay Description:Agonist activity at human H4R expressed in HEK293 cells co-expressing ELucC/ELucN-beta-arrestin2 assessed as induction of beta-arrestin recruitment b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50538678(CHEMBL4642520)
Affinity DataKd:  80nMAssay Description:Binding affinity to human recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50538678(CHEMBL4642520)
Affinity DataKd:  78nMAssay Description:Binding affinity to human recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50538678(CHEMBL4642520)
Affinity DataKd:  0.970nMAssay Description:Binding affinity to human recombinant NLuc/GPCR-fused H3R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50538678(CHEMBL4642520)
Affinity DataKd:  0.970nMAssay Description:Binding affinity to human recombinant NLuc/GPCR-fused H3R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetHistamine H4 receptor(Mouse)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50538678(CHEMBL4642520)
Affinity DataKd:  154nMAssay Description:Binding affinity to mouse recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetHistamine H4 receptor(Mouse)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50538678(CHEMBL4642520)
Affinity DataKd:  162nMAssay Description:Binding affinity to mouse recombinant NLuc/GPCR-fused H4R expressed in HEK293T cells measured after 30 mins by furimazine substrate based BRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50538678(CHEMBL4642520)
Affinity DataKi:  0.912nMAssay Description:Displacement of [3H]-UR-PI294 from Galphai2/Gbeta1gamma2-coupled human recombinant H3R expressed in baculovirus infected Sf9 insect cell membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50538678(CHEMBL4642520)
Affinity DataKi:  34nMAssay Description:Displacement of [3H]-histamine from Galphai2/Gbeta1gamma2-coupled human recombinant H4R expressed in baculovirus infected Sf9 insect cell membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetHistamine H2 receptor(Human)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50538678(CHEMBL4642520)
Affinity DataKi:  1.82E+3nMAssay Description:Displacement of [3H]UR-DE257 from Gsalphas-coupled human recombinant H2R expressed in baculovirus infected Sf9 insect cell membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetHistamine H1 receptor(Human)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50538678(CHEMBL4642520)
Affinity DataKi: <4.79E+3nMAssay Description:Displacement of [3H]pyrilamine from human recombinant H1R expressed in baculovirus infected Sf9 insect cell membranes co-expressing RGS4More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed