BDBM50538648 CHEMBL4640415

SMILES ONC(=O)c1ccc(NC(=O)C2(CCCC2)c2ccc(cc2)-c2cccc(c2)C(O)=O)cc1

InChI Key InChIKey=LXUDZYCOGQLEHS-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50538648   

TargetHistone deacetylase 1(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50538648(CHEMBL4640415)
Affinity DataIC50: 2nMAssay Description:Inhibition of human recombinant HDAC1 pre-incubated for 30 mins before Ac-Leu- Gly-Lys(Ac)-AMC substrate addition and measured after 90 mins by fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMed
TargetHistone deacetylase 2(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50538648(CHEMBL4640415)
Affinity DataIC50: 13nMAssay Description:Inhibition of human recombinant HDAC2 pre-incubated for 30 mins before Ac-Leu- Gly-Lys(Ac)-AMC substrate addition and measured after 90 mins by fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMed
TargetHistone deacetylase 3(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50538648(CHEMBL4640415)
Affinity DataIC50: 7nMAssay Description:Inhibition of human recombinant HDAC3 pre-incubated for 30 mins before Ac-Leu- Gly-Lys(Ac)-AMC substrate addition and measured after 90 mins by fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMed
TargetHistone deacetylase 8(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50538648(CHEMBL4640415)
Affinity DataIC50: 118nMAssay Description:Inhibition of human recombinant HDAC8 pre-incubated for 30 mins before Ac-Leu- Gly-Lys(Ac)-AMC substrate addition and measured after 90 mins by fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMed
TargetHistone deacetylase 7(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50538648(CHEMBL4640415)
Affinity DataIC50: 920nMAssay Description:Inhibition of human recombinant HDAC7 pre-incubated for 15 mins before Ac-Leu-Gly-Lys(trifluroAc)-AMC substrate addition and measured after 60 mins b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMed