BDBM50538634 CHEMBL4640356

SMILES ONC(=O)c1ccc(NC(=O)C2(CCCC2)c2c[nH]c(n2)-c2ccccc2)cc1

InChI Key InChIKey=FWWDOIFRDPDMSA-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50538634   

TargetHistone deacetylase 1(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50538634(CHEMBL4640356)
Affinity DataIC50: 3nMAssay Description:Inhibition of human recombinant HDAC1 pre-incubated for 30 mins before Ac-Leu- Gly-Lys(Ac)-AMC substrate addition and measured after 90 mins by fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMed
TargetHistone deacetylase 2(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50538634(CHEMBL4640356)
Affinity DataIC50: 21nMAssay Description:Inhibition of human recombinant HDAC2 pre-incubated for 30 mins before Ac-Leu- Gly-Lys(Ac)-AMC substrate addition and measured after 90 mins by fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMed
TargetHistone deacetylase 3(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50538634(CHEMBL4640356)
Affinity DataIC50: 10nMAssay Description:Inhibition of human recombinant HDAC3 pre-incubated for 30 mins before Ac-Leu- Gly-Lys(Ac)-AMC substrate addition and measured after 90 mins by fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMed
TargetHistone deacetylase 8(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50538634(CHEMBL4640356)
Affinity DataIC50: 41nMAssay Description:Inhibition of human recombinant HDAC8 pre-incubated for 30 mins before Ac-Leu- Gly-Lys(Ac)-AMC substrate addition and measured after 90 mins by fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMed
TargetHistone deacetylase 7(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50538634(CHEMBL4640356)
Affinity DataIC50: 470nMAssay Description:Inhibition of human recombinant HDAC7 pre-incubated for 15 mins before Ac-Leu-Gly-Lys(trifluroAc)-AMC substrate addition and measured after 60 mins b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMed