BDBM50538573 CHEMBL4638960

SMILES Cc1cc(Cl)cc(c1CN1CCNCC1)-c1ccnc2cc(CN3C(=O)CCC3=O)sc12

InChI Key InChIKey=MJVNKLYUWIPXLC-UHFFFAOYSA-N

Data  1 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50538573   

TargetUbiquitin carboxyl-terminal hydrolase 7(Human)
Rapt Therapeutics

Curated by ChEMBL
LigandPNGBDBM50538573(CHEMBL4638960)
Affinity DataIC50: 32nMAssay Description:Inhibition of recombinant full length USP7 (unknown origin) using ubiquintin-rhodamine as substrate preincubated for 30 mins followed by substrate ad...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMed
TargetUbiquitin carboxyl-terminal hydrolase 7(Human)
Rapt Therapeutics

Curated by ChEMBL
LigandPNGBDBM50538573(CHEMBL4638960)
Affinity DataEC50:  1.20E+3nMAssay Description:Inhibition of USP7 in human RKO cells transfected with p53 luciferase reporter vector assessed as increase in p53-dependent luciferase activity measu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMed