BDBM50538479 CHEMBL4634320::US11396496, Compound C1

SMILES COc1ccc(cc1)S(=O)(=O)Cc1ccc(NS(=O)(=O)c2ccc(OC)cc2)c2ccccc12

InChI Key InChIKey=UAQWWYCFJATMOR-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50538479   

TargetKelch-like ECH-associated protein 1(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50538479(CHEMBL4634320 | US11396496, Compound C1)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of FITC-9mer Nrf2 peptide binding to recombinant human KEAP1 Kelch domain (321 to 609 residues) expressed in Escherichia coli BL21 (DE3) b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMed
LigandPNGBDBM50538479(CHEMBL4634320 | US11396496, Compound C1)
Affinity DataIC50: 2.90E+3nMAssay Description:The IC50 of the compounds for inhibiting the interaction of a fluorescent NRF2 peptide and the Kelch domain of KEAP1 was determined using fluorescenc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2022
Entry Details
Go to US Patent