BDBM50538476 CHEMBL4649400

SMILES Nc1cncc(c1)-c1cn2ccnc2c(Nc2ccc(cc2)N2CCN(CC2)C2COC2)n1

InChI Key InChIKey=FHHOTRFQSOFYNC-UHFFFAOYSA-N

Data  1 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50538476   

TargetTyrosine-protein kinase SYK(Human)
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50538476(CHEMBL4649400)
Affinity DataIC50: 29nMAssay Description:Inhibition of SYK (unknown origin) using XL665-labeled peptide as substrate in presence of ATP measured after 30 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase SYK(Human)
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50538476(CHEMBL4649400)
Affinity DataEC50:  162nMAssay Description:Inhibition of SYK in human Ramos cells assessed as reduction in antihuman IgM F(ab)2-induced phosphorylation of BLNK at Y96 residue preincubated for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase SYK(Human)
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50538476(CHEMBL4649400)
Affinity DataEC50:  196nMAssay Description:Inhibition of SYK in human whole blood assessed as reduction in anti-FCepsilonR1 mAb-induced basophil activation by measuring decrease in CD63 surfac...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMed