BDBM50538449 CHEMBL4633338

SMILES C1OCC11CN(C1)c1ccc(Nc2nc(cn3ccnc23)-c2ccc3cn[nH]c3c2)cc1

InChI Key InChIKey=IUESGRQIZDYJES-UHFFFAOYSA-N

Data  1 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50538449   

TargetTyrosine-protein kinase SYK(Human)
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50538449(CHEMBL4633338)
Affinity DataIC50: 5nMAssay Description:Inhibition of SYK (unknown origin) using XL665-labeled peptide as substrate in presence of ATP measured after 30 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase SYK(Human)
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50538449(CHEMBL4633338)
Affinity DataEC50:  63nMAssay Description:Inhibition of SYK in human Ramos cells assessed as reduction in antihuman IgM F(ab)2-induced phosphorylation of BLNK at Y96 residue preincubated for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase SYK(Human)
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50538449(CHEMBL4633338)
Affinity DataEC50:  1.50E+3nMAssay Description:Inhibition of SYK in human whole blood assessed as reduction in anti-FCepsilonR1 mAb-induced basophil activation by measuring decrease in CD63 surfac...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMed