BDBM50538440 CHEMBL4642144

SMILES Cc1ccc(cc1C#Cc1cnc2cccnn12)C(=O)Nc1ccc(CN2CCN(CCO)CC2)c(Cl)c1

InChI Key InChIKey=OVTAMJUJNVINGX-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50538440   

TargetTyrosine-protein kinase ABL1(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50538440(CHEMBL4642144)
Affinity DataIC50: 0.390nMAssay Description:Inhibition of human ABL1 assessed as residual activity using EAIYAAPFAKKK as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50538440(CHEMBL4642144)
Affinity DataIC50: 1.34E+4nMAssay Description:Inhibition of human recombinant CYP3A4 expressed in insect cell microsomes in presence of NADPH by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50538440(CHEMBL4642144)
Affinity DataIC50: 100nMAssay Description:Inhibition of human ERG incubated for 4 hrs by competitive fluorescence tracer binding based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMed