BDBM50538433 CHEMBL4633993

SMILES COc1nn(cc1C(=O)Nc1cccc(n1)-c1nncn1C(C)C)-c1cccnc1

InChI Key InChIKey=KHIKMRTUDHIHMX-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50538433   

LigandPNGBDBM50538433(CHEMBL4633993)
Affinity DataIC50: 5.30nMAssay Description:Inhibition of human ASK1 using myelin basic protein substrate preincubated for 20 mins before [33P]-ATP addition and measured after 2 hrs by filter-b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMed
LigandPNGBDBM50538433(CHEMBL4633993)
Affinity DataIC50: 11nMAssay Description:Inhibition of V5 tagged human ASK1 expressed in HEK293T cells assessed as reduction in T848 autophosphorylation incubated for 1 hr by MSD assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMed