BDBM50538428 CHEMBL4640063

SMILES CCn1cc(C(=O)Nc2cccc(n2)-c2nncn2C(C)C)c(OC)n1

InChI Key InChIKey=UGAQYDMHQFTUBE-UHFFFAOYSA-N

Data  2 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50538428   

TargetMitogen-activated protein kinase kinase kinase 5(Human)
Biogen

Curated by ChEMBL

LigandBDBM50538428(CHEMBL4640063)Copy SMILESCopy InChI

Affinity DataIC50: 4.10nMAssay Description:Inhibition of human ASK1 using myelin basic protein substrate preincubated for 20 mins before [33P]-ATP addition and measured after 2 hrs by filter-b...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
8/11/2021
Entry Details Article
Copy Entry DOIPubMed
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TargetMitogen-activated protein kinase kinase kinase 5(Human)
Biogen

Curated by ChEMBL

LigandBDBM50538428(CHEMBL4640063)Copy SMILESCopy InChI

Affinity DataIC50: 22nMAssay Description:Inhibition of V5 tagged human ASK1 expressed in HEK293T cells assessed as reduction in T848 autophosphorylation incubated for 1 hr by MSD assayMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
8/11/2021
Entry Details Article
Copy Entry DOIPubMed
Copy Rxn URL