BDBM50538420 CHEMBL4636825::US11236045, Example 56

SMILES O=C(Nc1c2CCCc2cc2CCCc12)NS(=O)(=NC#N)c1cccnc1

InChI Key InChIKey=BTNVNDWLDGUCMY-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50538420   

TargetNACHT, LRR and PYD domains-containing protein 3(Human)
Cadila Healthcare

Curated by ChEMBL
LigandPNGBDBM50538420(CHEMBL4636825 | US11236045, Example 56)
Affinity DataIC50: 36nMAssay Description:Inhibition of NLRP3 inflammasome activation in LPS-primed human THP1 cells assessed as reduction in IL-1beta level preincubated for 1 hr followed by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Human)
Cadila Healthcare

Curated by ChEMBL
LigandPNGBDBM50538420(CHEMBL4636825 | US11236045, Example 56)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of NLRP3 inflammasome activation in LPS-primed human THP1 cells assessed as reduction in TNF alpha level preincubated for 1 hr followed by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMed
TargetUromodulin(Human)
Cadila Healthcare

US Patent
LigandPNGBDBM50538420(CHEMBL4636825 | US11236045, Example 56)
Affinity DataIC50: 43nMAssay Description:THP1 (Tamm-Horsfall Protein 1) monocytes were differentiated with PMA (Phorbol 12-myristate 13-acetate) (100 ng/ml) and incubated at 37° C. for 20 h ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2022
Entry Details
Go to US Patent