BDBM50538188 CHEMBL4649310

SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)c1cnccn1)C(=O)[C@@]1(C)CO1

InChI Key InChIKey=UUQDSBNKBWJJPD-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50538188   

TargetProteasome subunit beta type-9(Human)
University of Kentucky

Curated by ChEMBL
LigandPNGBDBM50538188(CHEMBL4649310)
Affinity DataIC50: 70nMAssay Description:Inhibition of LMP2 in human 20S immunoproteasome using Ac-PAL-AMC as substrate after 1 hr by fluorescence based microplate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMed
TargetProteasome subunit beta type-1(Human)
University of Kentucky

Curated by ChEMBL
LigandPNGBDBM50538188(CHEMBL4649310)
Affinity DataIC50: 590nMAssay Description:Inhibition of Beta1 subunit in human 20S proteasome using Ac-nLPnLD-AMC as substrate after 1 hr by fluorescence based microplate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMed
TargetProteasome subunit beta type-8(Human)
University of Kentucky

Curated by ChEMBL
LigandPNGBDBM50538188(CHEMBL4649310)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of LMP7 in human 20S immunoproteasome using Ac-ANW-AMC as substrate after 1 hr by fluorescence based microplate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMed
TargetProteasome subunit beta type-5(Human)
University of Kentucky

Curated by ChEMBL
LigandPNGBDBM50538188(CHEMBL4649310)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of Beta5 in human 20S immunoproteasome usingAc-WLA-AMC as substrate after 1 hr by fluorescence based microplate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMed
TargetProteasome subunit beta type-9(Human)
University of Kentucky

Curated by ChEMBL
LigandPNGBDBM50538188(CHEMBL4649310)
Affinity DataIC50: 71nMAssay Description:Inhibition of human 20S proteasome LMP2 using Ac-PAL-AMC as fluorogenic substrate measured every minute for 1 hr by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetProteasome subunit beta type-8(Human)
University of Kentucky

Curated by ChEMBL
LigandPNGBDBM50538188(CHEMBL4649310)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human 20S proteasome LMP7 using Ac-ANW-AMC as fluorogenic substrate measured every minute for 1 hr by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed