BDBM50537959 CHEMBL4541397

SMILES C[C@H](NCc1ccc2n(C[C@H]3CCCN3C(=O)C=C)\c(=N\C(=O)c3ccc(s3)C(F)F)[nH]c2c1)C(C)(C)C

InChI Key InChIKey=NXTKFBGDLDPFLB-UHFFFAOYSA-N

Data  1 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50537959   

TargetTyrosine-protein kinase ITK/TSK(Human)
Peking University

Curated by ChEMBL
LigandPNGBDBM50537959(CHEMBL4541397)
Affinity DataIC50: 3.20nMAssay Description:Inhibition of ITK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase ITK/TSK(Human)
Peking University

Curated by ChEMBL
LigandPNGBDBM50537959(CHEMBL4541397)
Affinity DataEC50:  157nMAssay Description:Inhibition of ITK in anti-CD3/CD28 beads-stimulated human Jurkat cells assessed as reduction in Plcgamma1 phosphorylation incubated for 2 hrs followe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMed