BDBM50537741 CHEMBL4637209::US11179389, Compound 1-18

SMILES C[C@@H]1CN(CCN1C(=O)C1CC1)c1cnc(C#N)c(n1)-c1cnn(C)c1

InChI Key InChIKey=PKHDHJSKOLMIMB-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50537741   

LigandPNGBDBM50537741(CHEMBL4637209 | US11179389, Compound 1-18)
Affinity DataIC50: 33nMAssay Description:Inhibition of recombinant human full-length N-terminal GST-tagged p110delta/untagged full-length p85alpha expressed in baculovirus infected Sf21 cell...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMed
LigandPNGBDBM50537741(CHEMBL4637209 | US11179389, Compound 1-18)
Affinity DataIC50: 219nMAssay Description:Inhibition of PI3K delta in human whole blood assessed as inhibition of anti-IgE-stimulated CysLt release in basophils preincubated for 30 mins follo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMed
LigandPNGBDBM50537741(CHEMBL4637209 | US11179389, Compound 1-18)
Affinity DataIC50: 33nMAssay Description:The PI3-Kinase biochemical assay was optimized using the HTRF kit provided by Upstate (Millipore). The assay kit contains six reagents: 1) 4×Reaction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/10/2022
Entry Details
Go to US Patent

LigandPNGBDBM50537741(CHEMBL4637209 | US11179389, Compound 1-18)
Affinity DataIC50: 16nMAssay Description:The PI3-Kinase biochemical assay was optimized using the HTRF kit provided by Upstate (Millipore). The assay kit contains six reagents: 1) 4×Reaction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/10/2022
Entry Details
Go to US Patent