BDBM50537740 CHEMBL4649678::US11179389, Compound 1-13

SMILES C[C@@H]1CN(CCN1C(=O)C1CC1)c1nc(cnc1C#N)-c1cnn(C)c1

InChI Key InChIKey=GLCGTMKCHJYJFD-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50537740   

LigandPNGBDBM50537740(CHEMBL4649678 | US11179389, Compound 1-13)
Affinity DataIC50: 737nMAssay Description:Inhibition of PI3K delta in human whole blood assessed as inhibition of anti-IgE-stimulated CysLt release in basophils preincubated for 30 mins follo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMed
LigandPNGBDBM50537740(CHEMBL4649678 | US11179389, Compound 1-13)
Affinity DataIC50: 185nMAssay Description:Inhibition of recombinant human full-length N-terminal GST-tagged p110delta/untagged full-length p85alpha expressed in baculovirus infected Sf21 cell...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMed
LigandPNGBDBM50537740(CHEMBL4649678 | US11179389, Compound 1-13)
Affinity DataIC50: 190nMAssay Description:The PI3-Kinase biochemical assay was optimized using the HTRF kit provided by Upstate (Millipore). The assay kit contains six reagents: 1) 4×Reaction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/10/2022
Entry Details
Go to US Patent