BDBM50537737 CHEMBL4642953

SMILES CC1CC1C(=O)N1CCN(C[C@H]1C)c1nc(ncc1C#N)-c1cnn(C)c1

InChI Key InChIKey=ZXXHAWWIMOPNIX-UHFFFAOYSA-N

Data  2 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50537737   

TargetPhosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Human)
Merck

Curated by ChEMBL

LigandBDBM50537737(CHEMBL4642953)Copy SMILESCopy InChI

Affinity DataIC50: 79nMAssay Description:Inhibition of recombinant human full-length N-terminal GST-tagged p110delta/untagged full-length p85alpha expressed in baculovirus infected Sf21 cell...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
8/11/2021
Entry Details Article
Copy Entry DOIPubMed
Copy Rxn URL

TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Human)
Merck

Curated by ChEMBL

LigandBDBM50537737(CHEMBL4642953)Copy SMILESCopy InChI

Affinity DataIC50: 557nMAssay Description:Inhibition of PI3K delta in human whole blood assessed as inhibition of anti-IgE-stimulated CysLt release in basophils preincubated for 30 mins follo...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
8/11/2021
Entry Details Article
Copy Entry DOIPubMed
Copy Rxn URL