BDBM50537734 CHEMBL4642225::US11230547, Compound 4-1

SMILES C[C@@H]1CN(CCN1C(=O)C1CC1)c1nc(ncc1C#N)-c1cnn(C)c1

InChI Key InChIKey=RIECHNBHNSMPHW-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50537734   

LigandPNGBDBM50537734(CHEMBL4642225 | US11230547, Compound 4-1)
Affinity DataIC50: 108nMAssay Description:Inhibition of recombinant human full-length N-terminal GST-tagged p110delta/untagged full-length p85alpha expressed in baculovirus infected Sf21 cell...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMed
LigandPNGBDBM50537734(CHEMBL4642225 | US11230547, Compound 4-1)
Affinity DataIC50: 329nMAssay Description:Inhibition of PI3K delta in human whole blood assessed as inhibition of anti-IgE-stimulated CysLt release in basophils preincubated for 30 mins follo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMed
LigandPNGBDBM50537734(CHEMBL4642225 | US11230547, Compound 4-1)
Affinity DataIC50: 110nMAssay Description:This assay was developed and further optimized from a kit produced by Upstate (Millipore catalog #33-047) (Millipore Sigma, Billerica Mass., USA) and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2022
Entry Details
Go to US Patent