BDBM50537731 CHEMBL4640567::US11230547, Compound 3-1

SMILES Cn1cc(cn1)-c1ncc(C#N)c(n1)N1CCN(c2cccc(F)c2)C(C)(C)C1

InChI Key InChIKey=LHBOCJIOQYAOLR-UHFFFAOYSA-N

Data  2 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50537731   

TargetPhosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Human)
Merck

Curated by ChEMBL

LigandBDBM50537731(CHEMBL4640567 | US11230547, Compound 3-1)Copy SMILESCopy InChI

Affinity DataIC50: 1.52E+3nMAssay Description:Inhibition of recombinant human full-length N-terminal GST-tagged p110delta/untagged full-length p85alpha expressed in baculovirus infected Sf21 cell...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
8/11/2021
Entry Details Article
Copy Entry DOIPubMed
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TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Human)
Merck Sharp & Dohme

US Patent

LigandBDBM50537731(CHEMBL4640567 | US11230547, Compound 3-1)Copy SMILESCopy InChI

Affinity DataIC50: 1.50E+3nMAssay Description:This assay was developed and further optimized from a kit produced by Upstate (Millipore catalog #33-047) (Millipore Sigma, Billerica Mass., USA) and...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
5/30/2022
Entry Details
Copy Entry DOIGo to US Patent

Copy Rxn URL