BDBM50537726 CHEMBL4635364::US11230547, Compound 2-2

SMILES [H][C@]12CN([C@]([H])(CN1c1nc(ncc1C#N)-c1cnn(C)c1)C2)S(=O)(=O)C1CC1

InChI Key InChIKey=AQNIGKMKZXSRSH-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50537726   

LigandPNGBDBM50537726(CHEMBL4635364 | US11230547, Compound 2-2)
Affinity DataIC50: 4.12E+3nMAssay Description:Inhibition of PI3K delta in human whole blood assessed as inhibition of anti-IgE-stimulated CysLt release in basophils preincubated for 30 mins follo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMed
LigandPNGBDBM50537726(CHEMBL4635364 | US11230547, Compound 2-2)
Affinity DataIC50: 1.19E+3nMAssay Description:Inhibition of recombinant human full-length N-terminal GST-tagged p110delta/untagged full-length p85alpha expressed in baculovirus infected Sf21 cell...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMed
LigandPNGBDBM50537726(CHEMBL4635364 | US11230547, Compound 2-2)
Affinity DataIC50: 1.20E+3nMAssay Description:This assay was developed and further optimized from a kit produced by Upstate (Millipore catalog #33-047) (Millipore Sigma, Billerica Mass., USA) and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2022
Entry Details
Go to US Patent