BDBM50537681 CHEMBL4640167

SMILES COc1cc(Nc2nc(Nc3ccc4[nH]ccc4c3)nnc2Cl)cc(OC)c1OC

InChI Key InChIKey=ZODYVVQSGBLLAM-UHFFFAOYSA-N

Data  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50537681   

TargetNEDD8-activating enzyme E1 regulatory subunit(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50537681(CHEMBL4640167)
Affinity DataEC50:  3.56E+3nMAssay Description:Inhibition of NAE-mediated neddylation in human MGC803 cells assessed as reduction in Nedd8-Ubcl2 adduct formation incubated for 24 hrs by Western bl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMed
TargetNEDD8-activating enzyme E1 regulatory subunit(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50537681(CHEMBL4640167)
Affinity DataEC50:  3.56E+3nMAssay Description:Inhibition of NAE-mediated neddylation in human MGC-803 cells assessed as effect on NEDD8-UBC12 coupling product formationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed