BDBM50537597 CHEMBL4645737::US11149020, Compound 6 (MW-105)

SMILES CN(C)c1cc(-c2ccncc2)c(nn1)-c1ccccc1

InChI Key InChIKey=JZNLARIEJUCAJO-UHFFFAOYSA-N

Data  1 KI  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50537597   

TargetMitogen-activated protein kinase 14(Human)
Columbia University

US Patent
LigandPNGBDBM50537597(CHEMBL4645737 | US11149020, Compound 6 (MW-105))
Affinity DataIC50: 543nMAssay Description:The concentration dependent ability of compounds to inhibit human p38α MAPK, p38β MAPK and CK-1δ were done essentially as described in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2022
Entry Details
Go to US Patent

TargetCasein kinase I isoform delta(Human)
Columbia University

US Patent
LigandPNGBDBM50537597(CHEMBL4645737 | US11149020, Compound 6 (MW-105))
Affinity DataIC50: 843nMAssay Description:The concentration dependent ability of compounds to inhibit human p38α MAPK, p38β MAPK and CK-1δ were done essentially as described in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2022
Entry Details
Go to US Patent

TargetMitogen-activated protein kinase 14(Human)
Columbia University

US Patent
LigandPNGBDBM50537597(CHEMBL4645737 | US11149020, Compound 6 (MW-105))
Affinity DataIC50: 490nMAssay Description:Inhibition of human p38alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 11(Human)
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50537597(CHEMBL4645737 | US11149020, Compound 6 (MW-105))
Affinity DataIC50: 8.02E+3nMAssay Description:Inhibition of human p38betaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMed
TargetCasein kinase I isoform delta(Human)
Columbia University

US Patent
LigandPNGBDBM50537597(CHEMBL4645737 | US11149020, Compound 6 (MW-105))
Affinity DataIC50: 710nMAssay Description:Inhibition of human CK1deltaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Columbia University

US Patent
LigandPNGBDBM50537597(CHEMBL4645737 | US11149020, Compound 6 (MW-105))
Affinity DataKi:  657nMAssay Description:The concentration dependent ability of compounds to inhibit human p38α MAPK, p38β MAPK and CK-1δ were done essentially as described in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2022
Entry Details
Go to US Patent