BDBM50537593 CHEMBL4639555::US11149020, Compound 3 (MW-066)

SMILES CN1CCN(CC1)c1cc(-c2ccncc2)c(nn1)-c1ccccc1

InChI Key InChIKey=CXPCCLCRWYXEET-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50537593   

TargetMitogen-activated protein kinase 14(Human)
Columbia University

US Patent
LigandPNGBDBM50537593(CHEMBL4639555 | US11149020, Compound 3 (MW-066))
Affinity DataIC50: 481nMAssay Description:The concentration dependent ability of compounds to inhibit human p38α MAPK, p38β MAPK and CK-1δ were done essentially as described in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2022
Entry Details
Go to US Patent

TargetCasein kinase I isoform delta(Human)
Columbia University

US Patent
LigandPNGBDBM50537593(CHEMBL4639555 | US11149020, Compound 3 (MW-066))
Affinity DataIC50: 130nMAssay Description:The concentration dependent ability of compounds to inhibit human p38α MAPK, p38β MAPK and CK-1δ were done essentially as described in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2022
Entry Details
Go to US Patent

TargetMitogen-activated protein kinase 14(Human)
Columbia University

US Patent
LigandPNGBDBM50537593(CHEMBL4639555 | US11149020, Compound 3 (MW-066))
Affinity DataIC50: 600nMAssay Description:Inhibition of human p38alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 11(Human)
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50537593(CHEMBL4639555 | US11149020, Compound 3 (MW-066))
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human p38betaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMed
TargetCasein kinase I isoform delta(Human)
Columbia University

US Patent
LigandPNGBDBM50537593(CHEMBL4639555 | US11149020, Compound 3 (MW-066))
Affinity DataIC50: 110nMAssay Description:Inhibition of human CK1deltaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMed