BDBM50537478 CHEMBL4574697

SMILES ONC(=O)\C=C\c1ccc(cc1)C(=O)NC(Cc1c[nH]c2ccccc12)C(=O)Nc1ccc(Cl)cc1

InChI Key InChIKey=MQWJSZLCUHDPRW-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50537478   

TargetHistone deacetylase 11(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50537478(CHEMBL4574697)
Affinity DataIC50: 1.37E+3nMAssay Description:Inhibition of HDAC11 (unknown origin) using Ac-Leu-GlyLys(Ac)-AMC as substrate preincubated for 5 mins followed by substrate addition and measured af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50537478(CHEMBL4574697)
Affinity DataIC50: 5.90nMAssay Description:Inhibition of HDAC1 (unknown origin) using Ac-Leu-GlyLys(Ac)-AMC as substrate preincubated for 5 mins followed by substrate addition and measured aft...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetHistone deacetylase(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50537478(CHEMBL4574697)
Affinity DataIC50: 35nMAssay Description:Inhibition of HDAC in human HeLa nuclear extract using Boc-Lys(Ac)-AMC as substrate preincubated for 5 mins followed by substrate addition and measur...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetHistone deacetylase 6(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50537478(CHEMBL4574697)
Affinity DataIC50: 2.86E+3nMAssay Description:Inhibition of HDAC6 (unknown origin) using Ac-Leu-GlyLys(Ac)-AMC as substrate preincubated for 5 mins followed by substrate addition and measured aft...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetHistone deacetylase 8(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50537478(CHEMBL4574697)
Affinity DataIC50: 243nMAssay Description:Inhibition of HDAC8 (unknown origin) using Ac-Leu-GlyLys(Ac)-AMC as substrate preincubated for 5 mins followed by substrate addition and measured aft...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed