BDBM50537412 CHEMBL4534172::US20240199677, Compound Tunicamycin

SMILES CC(C)CCCCCCCCC/C=C/C(=O)N[C@@H]1[C@H]([C@H]([C@H](O[C@H]1O[C@@H]2[C@@H]([C@H]([C@@H]([C@H](O2)CO)O)O)NC(=O)C)C[C@H]([C@@H]3[C@H]([C@H]([C@@H](O3)N4C=CC(=O)NC4=O)O)O)O)O)O

InChI Key InChIKey=MEYZYGMYMLNUHJ-UHFFFAOYSA-N

Data  4 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50537412   

TargetPhospho-N-acetylmuramoyl-pentapeptide-transferase(Staphylococcus aureus)
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50537412(CHEMBL4534172 | US20240199677, Compound Tunicamyci...)
Affinity DataIC50: 350nMAssay Description:Inhibition of Staphylococcus aureus MraY assessed as reduction in dansylated lipid I formation using UDP-MurNAc-dansylpentapeptide incubated for 3 hr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetPhospho-N-acetylmuramoyl-pentapeptide-transferase(Staphylococcus aureus)
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50537412(CHEMBL4534172 | US20240199677, Compound Tunicamyci...)
Affinity DataIC50: 350nMAssay Description:Inhibition of Staphylococcus aureus MraY assessed as reduction in dansylated lipid I formation using UDP-MurNAc-dansylpentapeptide incubated for 3 hr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetDecaprenyl-phosphate N-acetylglucosaminephosphotransferase(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
California Institute Of Technology

US Patent
LigandPNGBDBM50537412(CHEMBL4534172 | US20240199677, Compound Tunicamyci...)
Affinity DataIC50: 150nMAssay Description:UDP-Glucosamine-C6-FITC (2 mM stock solution, 0.56 L), MgCl2 (0.5 M, 4 μL), β-mercaptoethanol (50 mM, 5 μL), CHAPS (5%, 11.25 μL)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2024
Entry Details
Go to US Patent

TargetPhospho-N-acetylmuramoyl-pentapeptide-transferase(Mycobacterium bovis (strain BCG / Tokyo 172 / ATCC...)
California Institute Of Technology

US Patent
LigandPNGBDBM50537412(CHEMBL4534172 | US20240199677, Compound Tunicamyci...)
Affinity DataIC50: 3.38E+3nMAssay Description:Park's nucleotide-N -C6-dansyl (2 mM stock solution, 1.88 μL), MgCl2 (0.5 M, 5 L), KCI (2 M, 5 μL), Triton X-100 (0.5%, 5.63 μL), ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2024
Entry Details
Go to US Patent