BDBM50537138 CHEMBL4531690

SMILES Clc1cc2OCCOCCNc3ccn4ncc(-c(c1)c2)c4n3

InChI Key InChIKey=KTSDBMVHAKWDRK-UHFFFAOYSA-N

Data  1 KI  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50537138   

TargetCyclin-G-associated kinase(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50537138(CHEMBL4531690)
Affinity DataIC50: 0.0600nMAssay Description:Displacement of fluorescent tracer from N-terminus of human GAK expressed in HEK293T cells after 2 hrs by NanoBRET target engagement assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 2(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50537138(CHEMBL4531690)
Affinity DataIC50: 0.0110nMAssay Description:Displacement of fluorescent tracer from N-terminus of human RIPK2 expressed in HEK293T cells after 2 hrs by NanoBRET target engagement assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 2(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50537138(CHEMBL4531690)
Affinity DataIC50: 5.30nMAssay Description:Inhibition of recombinant RIPK2 (unknown origin) expressed in insect cells using RBER-CHKtide as substrate assessed as inhibition of tyrosine autopho...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 2(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50537138(CHEMBL4531690)
Affinity DataIC50: 5.30nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 2(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50537138(CHEMBL4531690)
Affinity DataIC50: 5.30nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetCyclin-G-associated kinase(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50537138(CHEMBL4531690)
Affinity DataKi:  3.80nMAssay Description:Binding affinity to C-terminal AVI-tagged GAK (unknown origin) (12 to 347 residues) expressed in Escherichia coli after 1.5 hrs by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed