BDBM50536833 CHEMBL4546760

SMILES FCC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)c1ccc(F)c2ccccc12

InChI Key InChIKey=COZDKQNJDUPHIX-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50536833   

TargetCysteine protease ATG4B(Human)
Roche Pharma Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50536833(CHEMBL4546760)
Affinity DataIC50: 60nMAssay Description:Inhibition of ATG4B (unknown origin) expressed in HEK293T cells coexpressing HTRA4 and Actin-LC3B-dNGLuc after 24 hrs by luciferase release assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetCysteine protease ATG4B(Human)
Roche Pharma Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50536833(CHEMBL4546760)
Affinity DataIC50: 110nMAssay Description:Inhibition of ATG4B (unknown origin) using His-GATE-16-GST as substrate preincubated for 30 mins followed by substrate addition measured after 30 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetCysteine protease ATG4B(Human)
Roche Pharma Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50536833(CHEMBL4546760)
Affinity DataIC50: 100nMAssay Description:Inhibition of ATG4B (unknown origin) using FRETGATE-16 as substrate incubated for 30 mins by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed