BDBM50536705 CHEMBL4572894

SMILES Fc1cccc(F)c1[C@H]1OC(=O)N[C@@H]1c1cncc(c1)C#Cc1ccccc1

InChI Key InChIKey=QXEDAJIHJMNCKU-UHFFFAOYSA-N

Data  1 KI  1 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50536705   

TargetMetabotropic glutamate receptor 5(Human)
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50536705(CHEMBL4572894)
Affinity DataEC50: >3.00E+3nMAssay Description:Positive allosteric modulation of human mGluR5A transfected in HEK293 cells assessed as potentiation of L-glutamate-induced calcium release incubated...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50536705(CHEMBL4572894)
Affinity DataEC50: >3.00E+3nMAssay Description:Agonist activity at human mGluR5A transfected in HEK293 cells assessed as induction of calcium release by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50536705(CHEMBL4572894)
Affinity DataIC50: 27nMAssay Description:Negative allosteric modulation of human mGluR5A transfected in HEK293 cells assessed as inhibition of L-glutamate-induced calcium release after 10 mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50536705(CHEMBL4572894)
Affinity DataKi:  2.70nMAssay Description:Displacement of [3H]-MPEPy from human mGluR5A transfected in HEK293 cell membranes after 60 mins by microbeta liquid scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed