BDBM50536646 CHEMBL4557930

SMILES COc1ccc(cn1)-c1c(CO)n(Cc2ccccc2Cl)c2ccc(OC(F)(F)F)cc12

InChI Key InChIKey=YYPCMHMJIQOTMJ-UHFFFAOYSA-N

Data  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50536646   

TargetCytochrome P450 3A4(Human)
Northwest Agriculture & Forestry University

Curated by ChEMBL
LigandPNGBDBM50536646(CHEMBL4557930)
Affinity DataIC50: 1.40E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes incubated for 15 mins using midazolam substrate in presence of NADPH by LC-MS/MS methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetProteinase-activated receptor 4(Human)
Northwest Agriculture & Forestry University

Curated by ChEMBL
LigandPNGBDBM50536646(CHEMBL4557930)
Affinity DataIC50: 9.40E+3nMAssay Description:Antagonist activity at PAR4 TL domain in human platelets assessed as gamma-thrombin-induced PAC1 binding response preincubated for 20 mins followed b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Northwest Agriculture & Forestry University

Curated by ChEMBL
LigandPNGBDBM50536646(CHEMBL4557930)
Affinity DataIC50: 4.20E+3nMAssay Description:Inhibition of CYP1A2 in human liver microsomes incubated for 15 mins using phenacetin substrate in presence of NADPH by LC-MS/MS methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetProteinase-activated receptor 4(Human)
Northwest Agriculture & Forestry University

Curated by ChEMBL
LigandPNGBDBM50536646(CHEMBL4557930)
Affinity DataIC50: 490nMAssay Description:Antagonist activity against PAR4 activating peptide domain in human platelets assessed as inhibition of alpha2bbeta3 activation level by PAC1 binding...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetProteinase-activated receptor 4(Human)
Northwest Agriculture & Forestry University

Curated by ChEMBL
LigandPNGBDBM50536646(CHEMBL4557930)
Affinity DataIC50: 450nMAssay Description:Antagonist activity against PAR4 activating peptide domain in human platelets assessed as inhibition of alpha2bbeta3 activation level by PAC1 binding...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetProteinase-activated receptor 4(Human)
Northwest Agriculture & Forestry University

Curated by ChEMBL
LigandPNGBDBM50536646(CHEMBL4557930)
Affinity DataIC50: 435nMAssay Description:Antagonist activity against PAR4 activating peptide domain in in human platelets assessed as inhibition of P-selectin activationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetProteinase-activated receptor 4(Human)
Northwest Agriculture & Forestry University

Curated by ChEMBL
LigandPNGBDBM50536646(CHEMBL4557930)
Affinity DataIC50: 1.00E+4nMAssay Description:Antagonist activity at PAR4 TL domain in human platelets assessed as gamma-thrombin-induced P-selectin activation preincubated for 20 mins followed b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Northwest Agriculture & Forestry University

Curated by ChEMBL
LigandPNGBDBM50536646(CHEMBL4557930)
Affinity DataIC50: 6.80E+3nMAssay Description:Inhibition of CYP2C9 in human liver microsomes incubated for 15 mins using diclofenac substrate in presence of NADPH by LC-MS/MS methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Northwest Agriculture & Forestry University

Curated by ChEMBL
LigandPNGBDBM50536646(CHEMBL4557930)
Affinity DataIC50: 120nMAssay Description:Inhibition of CYP2D6 in human liver microsomes incubated for 15 mins using dextromethorphan substrate in presence of NADPH by LC-MS/MS methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetProteinase-activated receptor 1(Human)
Northwest Agriculture & Forestry University

Curated by ChEMBL
LigandPNGBDBM50536646(CHEMBL4557930)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of PAR1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed