BDBM50536413 CHEMBL4593011

SMILES COc1ncc(cc1NS(C)(=O)=O)-c1cc2COCc2c(c1)-c1nnc(C)o1

InChI Key InChIKey=ILVGVDFTLIQTIE-UHFFFAOYSA-N

Data  2 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50536413   

TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Human)
Glaxosmithkline R&D

Curated by ChEMBL

LigandBDBM50536413(CHEMBL4593011)Copy SMILESCopy InChI

Affinity DataIC50: 200nMAssay Description:Inhibition of PI3Kdelta in human PBMC assessed as reduction in cytostim-induced IFNgamma production after 20 hrs by electrochemiluminescence assayMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
3/2/2021
Entry Details Article
Copy Entry DOIPubMed
Copy Rxn URL

TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Human)
Glaxosmithkline R&D

Curated by ChEMBL

LigandBDBM50536413(CHEMBL4593011)Copy SMILESCopy InChI

Affinity DataIC50: 20nMAssay Description:Inhibition of PI3Kdelta (unknown origin) using PIP2 as substrate preincubated for 15 mins followed by substrate addition measured after 60 mins in pr...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
3/2/2021
Entry Details Article
Copy Entry DOIPubMed
Copy Rxn URL