BDBM50536218 CHEMBL4516561

SMILES CCS(=O)(=O)Nc1cc(cc2[nH]ncc12)-c1ccc(O)c(F)c1

InChI Key InChIKey=PQUWBTQUHMDJRP-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50536218   

TargetTyrosine-protein kinase JAK3(Human)
Leo Pharma

Curated by ChEMBL
LigandPNGBDBM50536218(CHEMBL4516561)
Affinity DataIC50: 10nMAssay Description:Inhibition of human His-tagged JAK3 expressed in baculovirus using biotin-synthetic peptide as substrate after 20 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Leo Pharma

Curated by ChEMBL
LigandPNGBDBM50536218(CHEMBL4516561)
Affinity DataIC50: 251nMAssay Description:Inhibition of human Gst-tagged TYK2 ( 871 to 1187 residues) expressed in baculovirus using biotin-synthetic peptide as substrate after 20 mins by HTR...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Leo Pharma

Curated by ChEMBL
LigandPNGBDBM50536218(CHEMBL4516561)
Affinity DataIC50: 29nMAssay Description:Inhibition of human Gst-tagged JAK1 (850 to 1154 residues) expressed in baculovirus using biotin-synthetic peptide as substrate after 40 mins by HTRF...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
LigandPNGBDBM50536218(CHEMBL4516561)
Affinity DataIC50: 1.59E+3nMAssay Description:Inhibition of JAK in human B lymphocyte cells assessed as suppression of IL4-induced STAT6 phosphorylation preincubated for 1 hr followed by IL4 addi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Leo Pharma

Curated by ChEMBL
LigandPNGBDBM50536218(CHEMBL4516561)
Affinity DataIC50: 7.90nMAssay Description:Inhibition of human His-tagged JAK2 expressed in baculovirus using biotin-synthetic peptide as substrate after 20 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed