BDBM50536209 CHEMBL4539949

SMILES CCc1cc(O)c(F)cc1-c1cc(NS(C)(=O)=O)c2cn[nH]c2c1

InChI Key InChIKey=ITJPSWLLFAUHHO-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50536209   

LigandPNGBDBM50536209(CHEMBL4539949)
Affinity DataIC50: 398nMAssay Description:Inhibition of JAK in human B lymphocyte cells assessed as suppression of IL4-induced STAT6 phosphorylation preincubated for 1 hr followed by IL4 addi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Leo Pharma

Curated by ChEMBL
LigandPNGBDBM50536209(CHEMBL4539949)
Affinity DataIC50: 7.90nMAssay Description:Inhibition of human His-tagged JAK2 expressed in baculovirus using biotin-synthetic peptide as substrate after 20 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Leo Pharma

Curated by ChEMBL
LigandPNGBDBM50536209(CHEMBL4539949)
Affinity DataIC50: 2.5nMAssay Description:Inhibition of human His-tagged JAK3 expressed in baculovirus using biotin-synthetic peptide as substrate after 20 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Leo Pharma

Curated by ChEMBL
LigandPNGBDBM50536209(CHEMBL4539949)
Affinity DataIC50: 4nMAssay Description:Inhibition of human Gst-tagged JAK1 (850 to 1154 residues) expressed in baculovirus using biotin-synthetic peptide as substrate after 40 mins by HTRF...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed