BDBM50536100 CHEMBL4522524

SMILES C[C@H]1NC(=O)c2cc([nH]c12)-c1cccn2c1nc(NC(C)(C)C)c(C)c2=O

InChI Key InChIKey=YYXJSPFGMAXZGZ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50536100   

TargetSerine/threonine-protein kinase pim-1(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50536100(CHEMBL4522524)
Affinity DataIC50: 3.10nMAssay Description:Inhibition of full length recombinant Pim-1 (unknown origin) assessed as reduction in phosphorylation of biotinylated-BAD peptide at Serine 112 resid...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase pim-2(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50536100(CHEMBL4522524)
Affinity DataIC50: 2.10nMAssay Description:Inhibition of full length recombinant Pim-2 (unknown origin) assessed as reduction in phosphorylation of biotinylated-BAD peptide at Serine 112 resid...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
LigandPNGBDBM50536100(CHEMBL4522524)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of pan Pim in human KMS-12-BM cells assessed as reduction in phosphorylation of biotinylated-BAD peptide at Serine 112 residue after 110 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed