BDBM50536008 CHEMBL4550647

SMILES CN1CCN(CC1)c1ccc(Nc2ncc3ncc(=O)n(-c4ccc(N)cc4)c3n2)cc1C

InChI Key InChIKey=JMGMBDLFPSVCHG-UHFFFAOYSA-N

Data  1 IC50  8 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50536008   

TargetReceptor-type tyrosine-protein kinase FLT3(Human)
East China University of Science & Technology

Curated by ChEMBL
LigandPNGBDBM50536008(CHEMBL4550647)
Affinity DataKd:  0.25nMAssay Description:Binding affinity to human partial length FLT3 D835V mutant (592 to 969 residues) expressed in mammalian expression system after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
East China University of Science & Technology

Curated by ChEMBL
LigandPNGBDBM50536008(CHEMBL4550647)
Affinity DataKd:  5nMAssay Description:Binding affinity to human partial length wild type FLT3 (592 to 969 residues) expressed in bacterial expression system after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
East China University of Science & Technology

Curated by ChEMBL
LigandPNGBDBM50536008(CHEMBL4550647)
Affinity DataKd:  1.80nMAssay Description:Binding affinity to human partial length FLT3 D835H mutant (592 to 969 residues) expressed in bacterial expression system after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
East China University of Science & Technology

Curated by ChEMBL
LigandPNGBDBM50536008(CHEMBL4550647)
Affinity DataKd:  2nMAssay Description:Binding affinity to human partial length FLT3 D835Y mutant (580 to 969 residues) expressed in bacterial expression system after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
East China University of Science & Technology

Curated by ChEMBL
LigandPNGBDBM50536008(CHEMBL4550647)
Affinity DataKd:  0.790nMAssay Description:Binding affinity to human partial length FLT3 ITD/D835V mutant expressed in mammalian expression system after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
East China University of Science & Technology

Curated by ChEMBL
LigandPNGBDBM50536008(CHEMBL4550647)
Affinity DataKd:  5.70nMAssay Description:Binding affinity to human partial length FLT3 ITD/F691L mutant expressed in mammalian expression system after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
East China University of Science & Technology

Curated by ChEMBL
LigandPNGBDBM50536008(CHEMBL4550647)
Affinity DataKd:  79nMAssay Description:Binding affinity to auto-inhibited human partial length wild type FLT3 (564 to 969 residues) expressed in mammalian expression system after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
East China University of Science & Technology

Curated by ChEMBL
LigandPNGBDBM50536008(CHEMBL4550647)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of human N-terminal GST-tagged FLT3 (564 to 993 residues) expressed in baculovirus expression system using peptide FAM-P2 as substrate inc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
East China University of Science & Technology

Curated by ChEMBL
LigandPNGBDBM50536008(CHEMBL4550647)
Affinity DataKd:  6.90nMAssay Description:Binding affinity to human partial length FLT3 ITD mutant expressed in bacterial expression system after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed