BDBM50534854 CHEMBL4544537

SMILES c1ccc(c(c1)Nc2cccc3c2CN(CCO3)S(=O)(=O)c4ccc(cc4)F)F

InChI Key InChIKey=HCJWPYDAKXNGHM-UHFFFAOYSA-N

Data  3 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50534854   

TargetNuclear receptor ROR-gamma(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50534854(CHEMBL4544537)
Affinity DataIC50: 60nMAssay Description:Displacement of [3H]T0901317 from N-6HN-MBP-Avi-TCS-tagged human RORgamma LBD (P260 to K518 residues) preincubated for 30 mins followed by ligand add...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetNuclear receptor ROR-gamma(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50534854(CHEMBL4544537)
Affinity DataIC50: 60nMAssay Description:Agonist activity at ROR gamma (unknown origin) by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetNuclear receptor ROR-gamma(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50534854(CHEMBL4544537)
Affinity DataIC50: 60nMAssay Description:Agonist activity at human RORgammatMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMedPDB3D3D Structure (crystal)